Scientists identify the protein DeltaFosB as the "master switch" that rewires the brain's memory and reward circuits, driving chronic cocaine addiction and relapse.

People struggling with many addictions, ranging from opioids to gambling, are reporting similar experiences in clinics, on ...

Research suggests the drugs have potential for prevention and harm reduction in substance use disorders, writes Ziyad Al-Aly People taking glucagon-like peptide-1 (GLP-1) receptor agonists often ...

Rutgers researchers have used neuroimaging to demonstrate that cocaine addiction alters the brain's system for evaluating how rewarding various outcomes associated ...

Researchers report October 25 in the journal Neuron that cocaine addiction disrupts the dopamine neurons that govern how we perceive and learn from rewards. Though people with cocaine addiction have ...

A new study reveals how cocaine use alters brain circuits tied to memory and reward, leaving the brain more vulnerable to relapse.

A large epidemiological study of more than 600,000 veterans with diabetes suggests GLP-1 weight-loss medications may reduce ...

Why do so many people relapse after quitting cocaine? A new study from The Hebrew University reveals that a specific "anti-reward" brain circuit becomes hyperactive during withdrawal-driving ...

Why do we chase a positive feeling, even when we know the risks might override the reward? A research team led by Kristijan Jovanoski at Oxford University’s Centre for Neural Circuits and Behavior ...