Targeted Oncology

IGF-1 and GLP-1 Shape Liposarcoma Development, Presenting Potential Targets

Dedifferentiated liposarcoma lacks effective IGF-1→PPAR-γ adipogenic signaling due to epigenetic silencing of PPAR-γ2, with ...
Medscape

Targeting Cancer Cells -- More Pathways, More Inhibitors, More Trials

The insulin and the IGF-1 pathway are closely intertwined. Both can bind the insulin receptor or the IGF receptor 1 (IGFR-1). IGF-2, on the other hand, can bind either IGFR-1 or the high-affinity IGFR ...
ascopubs.org

Identification of PDGFR-β activation as a potential bypass resistance pathway in a rhabdomyosarcoma (RMS) model of acquired resistance to IGF-1 receptor blockade.

IGF-1R inhibition effect on a yes/SFK bypass resistance pathway: Rational basis for cotargeting IGF-1R and yes/SFK kinase in rhabdomyosarcoma. Preclinical evidence of craniofacial adverse effect of ...