A recent study by Fred Hutch biochemist Christopher Lapointe, PhD, and his colleagues, uses innovative lab techniques to ...

The expression of many eukaryotic genes is regulated at the level of translation initiation. The first step in the initiation process is binding of the small ribosomal subunit (40S) to the mRNA. Since ...

In a new study, published in Cell, researchers describe a newfound mechanism for creating proteins in a giant DNA virus, comparable to a mechanism in eukaryotic cells. The finding challenges the dogma ...

PNAS is the world's most-cited multidisciplinary scientific serial. It publishes high-impact research reports, commentaries, perspectives, reviews, colloquium papers, and actions of the Academy. In ...

Researchers have solved the the structure of the complex formed when mRNA is being scanned to find the starting point for translating RNA into a protein. The discovery provides a new understanding of ...

The Pre-Initiation Complex (PIC), which consists of Mediator, TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA polymerase II (RNAPII), governs the expression of all protein-coding and most non-coding ...

In order to live, it is necessary for creatures not only to synthesize essential components, but also degrade harmful or superfluous components. Autophagy, an intracellular degradation system ...

The regulation of mRNA transcription plays a key role in relaying signals from the environment and during development into the gene expression program of a cell. During transcription initiation, a ...