Type I interferons are a family of cytokines that play a critical role in the immune system, particularly in antiviral defence and immunomodulation. In systemic lupus erythematosus (SLE), an ...

Researchers have discovered that Type I interferon (IFN) plays a key role in helping the immune system effectively target viruses, while stopping white blood cells from 'going rogue' and attacking the ...

Innate immune sensors—known as pattern recognition receptors (PRRs)—detect specific molecular components of bacterial or ...

In a recent study published in Science Immunology, researchers investigated whether individuals with breakthrough infections of severe coronavirus disease 2019 (COVID-19) pneumonia demonstrated normal ...

A team led by researchers at the University of Cologne has identified a protein called ANKIB1 that acts as a volume dial for the body’s frontline immune defenses, controlling how strongly cells ...

Ossification of the posterior longitudinal ligament (OPLL) is a progressive spinal disease characterized by ectopic bone formation in the spine, leading to severe neurological symptoms due to spinal ...

The results of a new longitudinal analysis cast doubt on the utility of serial interferon assessment. Baseline evaluation of interferon (IFN)-stimulated genes (ISGs) may be a useful tool for assessing ...

ATLANTA – In their continuing work to limit the impact of COVID-19, Emory University researchers have, for the first time in nonhuman primates, studied how modulating the signaling of type 1 ...

Advances in the treatment of gastroenteropancreatic poorly differentiated neuroendocrine carcinoma at our hospital. This is an ASCO Meeting Abstract from the 2024 ASCO Gastrointestinal Cancers ...

When our body fights an infection, the immune system must quickly activate defenses and trigger a beneficial inflammatory response. It’s just as important to be able to resolve that inflammation and ...

In adults with rheumatoid arthritis (RA), higher serum levels of interferon (IFN) alfa were linked to greater disease activity and autoantibody positivity; however, IFN-gamma showed no such link, and ...