Nature

C-Jun N-Terminal Kinase Signaling Pathway and Its Biological Implications

The C-Jun N-Terminal Kinase (JNK) signalling pathway plays a pivotal role in regulating cellular responses to stress and damage. As a member of the mitogen-activated protein kinase (MAPK) family, JNK ...
News Medical

KiNet web portal enhances study of kinase functions in cellular signaling pathways

Researchers from the Icahn School of Medicine at Mount Sinai have introduced KiNet, an interactive web portal designed to explore kinase-substrate interactions in human cellular systems. These ...
ascopubs.org

Clinical Activity of Mitogen-Activated Protein Kinase Inhibitors in Patients With MAP2K1 (MEK1)-Mutated Metastatic Cancers

NOTE. P < .00357 represents statistical significance after the Bonferroni correction. Abbreviations: MAPK, mitogen-activated protein kinase; NA, unable to be calculated; NR, not reached; OS, overall ...
News Medical

Scientists map how cinnamon’s bioactives interact with cancer signaling

Laboratory studies suggest cinnamon’s bioactive compounds can alter key cancer-related signaling pathways, but researchers caution that human trials are essential before any preventive or therapeutic ...