Kaleido Scope

Development of Genome-Guided Therapeutics for NF Based on Genetic Mutation Subsets

Due in part to information featured in previous blog posts, I’ve received several e-mails recently from individuals interested in learning more about genome-guided therapeutics for NF. The UAB NF ...
News Medical

Researchers identify a brief window of opportunity to prevent NF1-associated optic pathway glioma

Nearly 20% of children with NF1 develop pLGGs along the optic pathway, also known as NF1-associated optic pathway glioma (NF1-OPG). Despite many advances in cancer therapy, there are no definitive ...
Kaleido Scope

NF Clinic Update and a Review of Pediatric NF Clinical Care Guidelines for Optic Pathway Gliomas and Indications for Neuroimaging in Children with NF1

It has been several months since Dr. Lane Rutledge, who was our colleague in the UAB NF Clinic, passed away unexpectedly, and her absence has been felt by those of us in the NF Clinic as well as by ...
News Medical

RAS-MAPK inhibition halts spinal deformity in neurofibromatosis type 1 mouse model

Spinal deformities such as scoliosis and kyphosis are among the most serious complications of neurofibromatosis type 1 (NF1), a genetic disorder that affects about one in 3,000 people. These ...