Abstract: Cyclic peptides become attractive therapeutic candidates due to their diverse biological activities. However, existing deep learning-based sequence design models, such as ProteinMPNN, are ...

Abstract: RNA binding proteins (RBPs) play a crucial role in regulating biological functions through their interactions with specific RNAs, significantly impacting various life processes.

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This valuable work presents an interpretable protein-DNA Energy Associative (IDEA) model for predicting binding sites and affinities of DNA-binding proteins. While the method is convincing, it ...

Have you ever sensed your company’s innovation efforts stalling—not because of a lack of effort, but because something in the process feels off? Most leaders understand that innovation requires ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. We introduce a new computational approach for predicting organic crystalline ...

Comprehensive reference genomes have now been assembled for six ape species: siamang (a Southeast Asian gibbon), Sumatran orangutan, Bornean orangutan, gorilla, bonobo and chimpanzee. Areas of their ...

Deep generative models that learn from the distribution of natural protein sequences and structures may enable the design of new proteins with valuable functions. While the majority of today’s models ...

This image shows the three-dimensional genome structures of several chromosomes reported in a Dip-C study, which were used to train the new ChromoGen model. Credits:Credit: Courtesy of the researchers ...

Every cell in a body contains the same genetic sequence, yet each cell expresses only a subset of those genes. These cell-specific gene expression patterns, which ensure that a brain cell is different ...